LSTM based Similarity Measurement with Spectral Clustering for Speaker Diarization

More and more neural network approaches have achieved considerable improvement upon submodules of speaker diarization system, including speaker change detection and segment-wise speaker embedding extraction. Still, in the clustering stage, traditional algorithms like probabilistic linear discriminant analysis (PLDA) are widely used for scoring the similarity between two speech segments. In this paper, we propose a supervised method to measure the similarity matrix between all segments of an audio recording with sequential bidirectional long short-term memory networks (Bi-LSTM). Spectral clustering is applied on top of the similarity matrix to further improve the performance. Experimental results show that our system significantly outperforms the state-of-the-art methods and achieves a diarization error rate of 6.63% on the NIST SRE 2000 CALLHOME database.Comment: Accepted for INTERSPEECH 201

LSTM based Similarity Measurement with Spectral Clustering for Speaker Diarization

International audienceMore and more neural network approaches have achieved considerable improvement upon submodules of speaker diarization system, including speaker change detection and segment-wise speaker embedding extraction. Still, in the clustering stage, traditional algorithms like probabilistic linear discriminant analysis (PLDA) are widely used for scoring the similarity between two speech segments. In this paper, we propose a supervised method to measure the similarity matrix between all segments of an audio recording with sequential bidirectional long short-term memory networks (Bi-LSTM). Spectral clustering is applied on top of the similarity matrix to further improve the performance. Experimental results show that our system significantly outperforms the state-of-the-art methods and achieves a diarization error rate of 6.63\% on the NIST SRE 2000 CALLHOME database

Research on Performance Deterioration of Internally Cured Pavement Concrete under the Coupling Effect of Salt Freeze–Thaw

This paper aims at solving the material durability problem caused by spraying deicing salt on pavement concrete in the northern winter. Super absorbent polymer (SAP) was adopted as an internal curing agent to enhance the durability of pavement concrete. Curing parameters including particle size and dosage of SAP and curing condition were optimized based on mortar tests by means of the grey target decision method. The deterioration rule of durability and mechanical properties of pavement concrete internally cured by different SAP dosages after salt freeze–thaw cycles were explored through rapid freeze–thaw test. Combined with the characteristics of pore structure, hydration and microstructure, the influence mechanism of SAP on the salt freeze–thaw resistance of pavement concrete was revealed. The experimental results showed that: (i) The reduction in mass loss rate and relative dynamic modulus was significantly improved by SAP internal curing with moderate dosage; (ii) The more freeze–thaw cycles the specimen underwent, the greater the increase in strength; (iii) After 75 cycles, the chloride ion erosion depth could be decreased by approximately 23.18%. Moreover, the addition of SAP could refine the pore size, inhibit the generation of shrinkage microcracks, and promote the degree of cement hydration in the late stage, which improved the internal density of the cement concrete structure. Therefore, the deterioration of pavement under the coupling effect of salt freeze–thaw was reduced

Highly Hydrophobic Cotton Fabrics Modified by Poly(methylhydrogen)siloxane and Fluorinated Olefin: Characterization and Applications

Highly hydrophobic cotton fabrics were obtained with poly(methylhydrogen)siloxane (PMHS) and a further fluorinated olefin modification. The chemical structures and microstructures of PMHS-modified cotton fabrics were characterized, and application of the resultant cotton fabrics in stain resistance and oil–water separation was demonstrated. PMHS chains with very low surface energy were grafted onto cotton fabric by the dehydrogenation reaction between –Si–H of PMHS and –OH groups of cotton fabric at room temperature. The water contact angle of PMHS-modified cotton fabric was 141.7°, which provided the modified cotton fabric with good stain resistance to waterborne pollutants. The separation efficiency of diesel from water was higher than 92% for 20 repeatable separation cycles. A further improvement in stain resistance to oil was also demonstrated by a further addition reaction of 1H,1H,2H-perfluoro-1-decene with PMHS-modified cotton fabric

RYBP Inhibits Progression and Metastasis of Lung Cancer by Suppressing EGFR Signaling and Epithelial-Mesenchymal Transition

Lung cancer (LC) is a common lethal malignancy with rapid progression and metastasis, and Ring1 and YY1 binding protein (RYBP) has been shown to suppress cell growth in human cancers. This study aimed to investigate the role of RYBP in LC progression and metastasis. In this study, a total of 149 LC patients were recruited, and the clinical stage of their tumors, metastasis status, survival time, presence of epidermal growth factor receptor (EGFR) mutation, and RYBP expression levels were measured. RYBP silencing and overexpression were experimentally performed in LC cell lines and in nude mice, and the expressions of genes in EGFR-related signaling pathways and epithelial-mesenchymal transition (EMT) were detected. The results showed that RYBP was downregulated in LC compared with adjacent normal tissues, and low RYBP expression was associated with a more severe clinical stage, high mortality, high metastasis risk, and poor survival. Cell proliferation and xenograft growth were inhibited by RYBP overexpression, whereas proliferation and xenograft growth were accelerated by RYBP silencing. EGFR and phosphorylated-EGFR levels were upregulated when RYBP was silenced, whereas EGFR, p-EGFR, p-AKT, and p-ERK were downregulated when RYBP was overexpressed. Low RYBP expression was related to a high metastasis risk, and metastasized tumors showed low RYBP levels. Cell migration and invasion were promoted by silencing RYBP but were inhibited by overexpressed RYBP. In addition, the EMT marker vimentin showed diminished expression, and E-cadherin was promoted by the overexpression of RYBP. In conclusion, our data suggest that RYBP suppresses cell proliferation and LC progression by impeding the EGFR-ERK and EGFR-AKT signaling pathways and thereby inhibiting cell migration and invasion and LC metastasis through the suppression of EMT

Additional file 5: of Direct measurement of pervasive weak repression by microRNAs and their role at the network level

Figure S3. Cumulative distribution of mRNA decay rates of with or without AU-rich, GU-rich and U-rich elements in 3’UTR, 5’UTR, Intron, Exon, and CDS simultaneously in (a) the WT and (b) KO line. AU-rich, GU-rich and U-rich element: ATTTA, AWTAAA, GTTTG, TTTGTTT, WTTTW, WWTTTWW, WWWTTTWWW, WWWWTTTWWWW, and WWWWWTTTWWWWW. W: A/U. P values are from Wilcoxon rank sum tests. (TIF 98 kb

Additional file 1: of Direct measurement of pervasive weak repression by microRNAs and their role at the network level

Figure S1. Correlation of all transcript and target expression (log2 transformed) between two biological replicates at 0 h, 2 h, 4 h, and 8 h. (a-d) results from the WT line, (e-h) results from the KO line. (TIF 368 kb